Bilateral, symmetric decreased FDG uptake in the tempo parietal region of the brain is the prevailing pattern observed in?

The prevailing pattern of bilateral, symmetric decreased FDG uptake in the tempo-parietal region of the brain is most commonly associated with Alzheimer's disease. In Alzheimer's, metabolic activity diminishes particularly in the parietal and temporal lobes, which correlates with the cognitive decline and memory deficits characteristic of the condition. This imaging pattern reflects the underlying neurodegeneration and the impact on glucose metabolism in these critical areas related to memory and cognitive function.

In contrast, other conditions like Pick disease, vascular disease, and dementia with Lewy bodies display different patterns of FDG uptake due to their distinct pathophysiological changes. For example, Pick disease typically involves frontal and temporal lobe atrophy, which may not present with the same symmetric pattern as seen in Alzheimer’s. Vascular disease often exhibits more focal areas of decreased uptake related to specific infarcts, while dementia with Lewy bodies may show more variability and can present regional uptake changes that are not symmetric. This differentiation is crucial for accurate diagnosis and understanding of the specific type of dementia.