Which radiopharmaceuticals are primarily excreted via the hepatobiliary system?

The correct option signifies that 99mTc-Sestamibi is primarily excreted via the hepatobiliary system. This radiopharmaceutical is commonly used in myocardial perfusion imaging and is known for its uptake by both cardiac and some non-cardiac tissues. Importantly, it undergoes a significant amount of hepatic metabolism, with a notable fraction of the radiopharmaceutical being excreted through the liver and into the biliary system. This characteristic helps differentiate it from other radiopharmaceuticals which may be excreted primarily through renal pathways.

In contrast, the other radiopharmaceuticals mentioned do not primarily utilize the hepatobiliary system for excretion. For example, 99mTc-Exametazime, which is often used in brain imaging, is predominantly taken up by brain tissues and excreted through the kidneys. Similarly, 99mTc-Medronate is used for bone scans and primarily removed via the renal system, not through the liver. Lastly, 201-Tl Thallous Chloride is used in cardiac imaging and has a different elimination pathway, mostly being cleared through the kidneys and not through the hepatobiliary system.

Understanding the metabolic pathways and excretory routes of radiopharmaceutical